Dynamin: switch or pinchase?
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منابع مشابه
Dynamin: switch or pinchase?
What is it? Dynamin is a protein that is essential for severing nascent endocytic pits from the plasma membrane to form vesicles. According to whom you speak, dynamin is either a molecular 'switch', or a pinchase-like mechanoenzyme. What is a switch and what is a mechanoenzyme? Small GTPases of the Ras superfamily are often thought of as switches that control cellular events. These enzymes, whe...
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and Schmid (1995) provided graphic images of dynamin, under low salt conditions, assembling into rings and spirals. These structures were of similar dimensions to the " collars " about the membrane invaginations ob-in Digestive Diseases served at the nerve terminals of mutant shibire ts flies self association of dynamin was shown not to require GTP binding or hydrolysis. Thus, dynamin is the se...
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متن کاملEndocytosis: Is dynamin a ‘blue collar’ or ‘white collar’ worker?
The GTPase dynamin clearly plays an important role in endocytosis, but precisely how has been controversial. Some recent results support the view that dynamin uses GTP hydrolysis physically to drive vesiculation; others support the view that dynamin acts as a classical G protein 'switch'. Perhaps both views are correct.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00513-9